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In humans, lithocholic acid (LCA) that derived from CDCA and deoxycholic acid (DCA) from CA are the two major secondary BAs, while MCA can be further converted into hyocholicacid (HCA) and hyodeoxycholic acid (HDCA) in rodents ( BA homeostasis is tightly regulated by enterohepatic signaling, whereas BA accumulation causes a series of diseases including inflammatory bowel disease, cholestatic hepatitis, primary biliary cirrhosis ( Huazhi-Rougan (HZRG) formula is a Chinese patent drug designed according to the theories of Traditional Chinese medicine (TCM)
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