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The claims of the named plaintiffs must be typical of those of the broader class

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Oxidative stress is responsible for disturbed signalling pathways which in turn affects, for example, molecular mechanisms of apoptosis induction, impairment of mitochondrial function, protein modification, and other mechanisms

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In Control cells, nutlin-3 treatment down-regulated numerous genes involved in nucleotide metabolism, including DTYMK , CTPS1 , RRM1 , and RRM2 (Fig 3B)