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Why Peptides Are Hard to Deliver Orally Peptides are generally vulnerable to proteolytic activity

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Sig Transduct Target Ther 11 , 144 (2026)

Cell culturing The T24 human bladder cancer cell line (Bio-73168, Chinese Microbial Culture Collection, Beijing, China) was obtained from the Chinese Microbial Culture Collection

It is worth to mention that available reports describing the encapsulation of GSH- or albumin-protected AuNCs are limited to hydrophilic, rather than hydrophobic, matrices such as nanogels 25 , aqueous core of microcapsules 26 , silica nanoparticles, protein nanoparticles 27,28 , polymer nanoparticles 29,30 and metal-organic frameworks 31

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