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Despite the cost (which is a bit of a stretch for me) it has been totally worth it

Everyones weight loss journey is unique, but initial weight loss tends to be rapid in the first few weeks

Future randomised controlled trials should specifically address this clinical question in older adults with obesity with an emphasis on efficacy, body composition and health economic modelling

Participants in the oral semaglutide arm underwent a dose-escalation schedule (3 mg daily for 4 weeks, followed by 7 mg daily for 4 weeks, then 14 mg daily for the remainder of the trial) to minimize gastrointestinal side effects

The samples were separated using a Zorbax Eclipse XDB-18 column (4.6 250 mm, 5 m) from Agilent (Santa Clara, CA, USA), protected by a guard column with the same packing

10.1038/s41586-024-07167-9 Nature 161 PetersonP