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In MCAS, mast cells inappropriately release massive amounts of histamine and other inflammatory mediators, causing widespread allergic-type symptoms, brain fog, and gastrointestinal distress

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nature (2012) 486:2227

In a healthy individual, this genetic bottleneck might only cause mild, subclinical issues

These effects are not only dependent on mechanical load, because the skeletal muscle may serve as an endocrine organ that is capable of secreting cytokines to modulate bone metabolism [3, 4]