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This may be explained by a relatively low trial drug exposure (76%) compared to other CVOTs, and that the trial had no run-in period and, therefore, had one of the highest discontinuation rates

Melasma usually responds best to a supervised combination of tretinoin and hydroquinone plus strict sun protection, rather than either alone

At 0.25mg for 4 weeks then 0.5mg for 4 weeks, you use 3mg total from the 5mg vial

in vitro 66 LiH.ZhangM.WangD.DongG.ChenZ.LiS.et al (2021b)