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Patients should seek urgent medical attention for severe persistent abdominal pain (especially if radiating to the back), persistent vomiting, jaundice, fever, inability to pass stool/gas, or abdominal distension, which could indicate serious complications such as pancreatitis, gallbladder disease, or intestinal obstruction

Long-term users report manageable side effects, which often diminish over time as the body adapts to the medication

Drug interactions have not been systematically evaluated

Structural modifications extend its half-life and reduce binding to IGF-binding proteins, allowing prolonged receptor interaction

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