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10.1080/17512433.2018.1457435 148 OteroD

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Additionally, VB also changed synaptic function by inducing extracellular Ca 2+ influx through L-type voltage-gated channels that activated the CaMKII pathway, upregulated synaptic vesicle-associated proteins and inhibited the activity of acetylcholinesterase (73)

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Supplementary Data 2 (download XLSX Raw data for plots in Supplementary Information

Slow titration schedules, typically adding one dose increment every four weeks, appear to reduce dropout rates due to gastrointestinal side effects