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We next employed a time-resolved cell-based quenching assay 56,57 , where we first bound hCCL1 AF647 to CHO.hCCR8 cells and then added unlabeled or quencher-labeled mAb1 (Fig

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The theory is that continuous high-dose GLP-1 agonist exposure can lead to partial receptor desensitization, and a brief period at a lower dose allows the receptors to upregulate

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