Recent findings also revealed concerns with the loss of skeletal muscle mass when taking GLP-1RAs with some studies reporting up to 50% of weight loss being due to decreases in muscle mass
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Only 28.8% of participants exceeded 1 mg/week
The analyses were conducted on the above cohorts: (1) SGLT2i and (2) GLP-1 RA with each analysis propensity score matched (PSM) for age, sex, BMI, presence of heart failure (ICD-10-CM-I50), hypertension (ICD-10-CM-I10), ischaemic heart disease (IHD) (ICD-10-CM-I2025), chronic kidney disease (CKD) (ICD-10-CM-N18) and HbA 1c value so as to balance the analysis (1:1 matching) being undertaken
Weeks 5-8: Weight Loss Becomes More Noticeable For many individuals, the second month is when measurable weight loss becomes more consistent
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