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As many of the factors responsible for the hyperpermeability tend to decrease in this stage, there is also an increase in factors that contribute to the restoration of BBB permeability, such as Ang-1, which keeps endothelial cells in a quiescent state and promotes cellcell and cellextracellular matrix interactions, sphingosine-1- phosphate, and activated protein C, both of which stabilize junctions and the cytoskeleton (3, 203)

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BioMed Research International , 2015

Cardiovascular Considerations BPC-157's effects on blood vessels deserve careful attention, especially if you have cardiovascular conditions or take blood pressure medications

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