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Abstract The objective of this study was to compare the effectiveness of subcutaneous (SC) and sublingual (SL) formulations of apomorphine for the treatment of motor fluctuations in Parkinsons disease using a pharmacokinetics (PK)/pharmacodynamics (PD) modeling approach

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The terminology is contested, but the underlying observation is not: the metabolic deterioration of neurons, their diminishing capacity to produce and manage energy, appears to be an early and potentially modifiable feature of the disease process, not merely a downstream consequence of it