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Unfortunately, due to the lack of high quality clinical trials with berberine to date, its difficult to defend its primary use in weight loss

doi: 10.1038/s41591-018-0238-9 259 ZhangRSPadegimasAMurphyKMEvansPTPetersCJDomenicoCMet al

An addiction can be physiological, which means it alters your body in a way that attempting to stop or cut down can cause a physical withdrawal, Gail Saltz, MD, associate professor of psychiatry at the NY Presbyterian Hospital Weill-Cornell School of Medicine, tells SELF

Omega-3 fatty acids reduce inflammatory signaling, which secondarily decreases DPP-4 gene transcription and enzyme production

Because doctors just, they just write prescriptions