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Archived from the original on April 24, 2010

Environmental cystine drives glutamine anaplerosis and sensitizes cancer cells to glutaminase inhibition

As a typical example, TCPP-based MOFs (TCPP: tetrakis (4-carboxyphenyl) porphyrin) are recognized as prospective nanophotosensitizers, such as Fe-TCPP, Mn-TCPP, and Cu-TCPP, which could be decomposed in overproduced GSH conditions, leading to intracellular GSH elimination (Wan et al., 2019

single and repeated IM dosing) characterized PK/ADME in dogs (e.g., single IV 6 g/kg

For a 250 mcg target dose at 2,500 mcg/mL: 250 2,500 = 0.1mL 100 = 10 units

Self-assembled copper-amino acid nanoparticles for in situ glutathione AND H2O2 sequentially triggered chemodynamic therapy