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The study confirmed FOXO4-DRI was effective across senescent cells generated by different methods (irradiation, doxorubicin, and replication stress), and documented that pre-treatment with FOXO4-DRI attenuated the dedifferentiation of chondrocytes during in vitro expansion establishing it as a valuable tool for research into senescent cell biology in cartilage and musculoskeletal models

For patients requiring long-term treatment, hydrogel carriers can provide continuous drug release and reduce the frequency of administration

Thus, suggesting that the low level of total GSH found in the EDTA-treated plasma stored at 4 o C is due to enzymatic degradation of total GSH rather than other biological processes [34]

Eluates were dried and then resolubilized in 100 L of 10% ACN prior to LC-MS/MS analysis

Many patients prefer to have one hand done first, recover briefly, and then schedule the second hand

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