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Ultimately, by harnessing two powerful hormones instead of one, dual-agonist therapy offers a more robust mechanism for weight management

This approach leverages the complementary actions of insulin, which lowers fasting and post-absorptive blood sugar levels, and GLP-1 agonists, which target postprandial blood sugar levels (6)

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This effect is consistent across GLP-1 receptor agonists and is thought to relate to increased sympathetic nervous system activity or reduced vagal tone

Patient selection criteria play a pivotal role in determining the most suitable medication