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This is supported at least in part at the biochemical level: the Km of L-cysteinyl-tRNA synthetase towards cysteine, which directs cysteine to translational machinery, is less than one tenth of that for other enzymes of cysteine metabolism such as GCS or cysteine dioxygenase 22

Overall, glutamate and glutathione are two distinct molecules with different functions

Jeon BN, Yoo JY, Choi WI, Lee CE, Yoon HG, Hur MW

Zhang XY, Wang DG, Duan YH, Zheng XY, Lin Y, Liang SL (2020) Production of lycopene by metabolically engineered Pichia pastoris

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