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This multi-target approach directly addresses the biological drivers of overeating and weight gain, rather than relying on indirect metabolic improvements

PMID: 80 MahakalkarS

As body composition changesparticularly with loss of adipose tissuethermoregulation is affected because fat serves primarily as insulation, while heat generation comes largely from metabolically active lean tissue

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Guerreiro CS, Carmona B, Goncalves S, Carolino E, Fidalgo P, Brito M, Leitao CN, Cravo M

In hippocampal neurons, this same pathway induces BDNF expression, suggesting potential neurotrophic and metabolic roles during development