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Dose appears to matter: the effect on drinking in the Lancet trial appeared at the full 2.4 mg dose, while the lower-dose JAMA Psychiatry trial found weaker real-world effects

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A patient-centered discussion on starting GLP-1s should consider the individuals circumstances, preferences, values, and medical conditions

Furthermore, co-treatment with a GLP-1R agonist and a GIPR agonist results in more insulin sensitivity, glucose reduction, food intake reduction, and body weight reduction than either agonist alone in obese mice with type 2 diabetes (33)