The imbalance of the redox status mediated by folate deficiency or methionine load has been characterized by various indices of oxidation such as increases in end-products of lipid oxidation (conjugated dienes, hydroperoxides, and thiobarbituric acid reactive substances), changes in the fatty acid composition with decreased polyunsaturated fatty acids (mostly n-3 fatty acids), and a lower antioxidant defense, as demonstrated using the free radical-mediated erythrocyte hemolysis test described in Durand and Blache (1996) and in Prost (1992)
Brison DR, Houghton FD, Falconer D, et al
In a natural state, $\alpha$-MSH is the primary endogenous ligand
The pressure of ADT leads to AR-activating alterations in androgen levels, the AR gene, and the elaborate and diverse molecular machinery that AR needs to engage to alter transcription of its target genes
However, more human clinical trials are still needed
In a study that will be published soon, Dr