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It says stimulant laxatives such as senna and bisacodyl can cause cramping and rebound constipation with prolonged use, which is why it does not treat them as a first-line option

11 However, the cost effectiveness of retreatment remains uncertain

J Clin Onco 2021 Gastrointestinal Cancers Symposium 39((suppl 3), 2021

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Last month, a report by the Commission on Government Forecasting & Accountability, the nonpartisan fiscal research arm of the Legislature, cited coverage of the weight-loss drugs as one driver of a nearly 17% increase in state group health insurance liabilities for the upcoming state fiscal year