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Randomised clinical trial: Design of the SYNERGY-NASH phase 2b trial to evaluate tirzepatide as a treatment for metabolic dysfunction-associated steatohepatitis and modification of screening strategy to reduce screen failures

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Since the region of the TK domain covering the ATP binding site is identical to that of the IR, such cross-inhibitions are not unexpected

This methodical, stepwise increase allows researchers to reach the target maintenance dose with minimal disruption and maximum subject retention

Patch test new combinations for 48 hours

Gooderham 2013