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23 MaiorinoM.ThomasJ
Gastrointestinal side effects have generally been consistent with those of incretin based therapies
Two reactions involving glucose metabolites catalyse the reduction of NADP+ to NADPH: glucose 6-phosphate dehydrogenase, forming 6-phosphogluconate, and phosphogluconate dehydrogenase, which yields the 5-carbon sugar ribulose 5-phosphate, liberating carbon dioxide from carbon-1 of the substrate
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Phase 2 studies showed therapeutic levels could be achieved in patients
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