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In my experience reviewing the pharmacokinetic data from Eli Lillys Phase 2 trials, this number is consistent and well-supported

[1] [2] It is essential to understand that these trial-specific details may not reflect the dosing schedule of any future approved product

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Moreover, small-molecule GLP-1RAs offer a solution to the bioavailability limitations faced by oral peptide-based agents, which often depend on absorption enhancers (e.g., SNAC) and strict fasting protocols [74]

Its what makes them sustainable.

Its important to note that its generally not recommended for women to take GLP-1s or other weight loss medications while looking to get pregnant, are currently pregnant, or are breastfeeding