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In 2022, 389,485 new OSCC cases and 188,230 related deaths were reported worldwide, yielding a case-fatality rate of 48%, and its incidence continues to rise annually ( 2 Research progress on ferroptosis in OSCC 2.1 Mechanisms of ferroptosis Ferroptosis is a regulated form of cell death driven by the iron-dependent accumulation of lethal lipid peroxides

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In addition, the treatment of nicotinamide (NAM), a form of vitamin B3, suppressed the activity of sirtuin-1 (SIRT1), a regulator of cellular stress resistance, and peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1), a key transcriptional coactivator involved in mitochondrial biogenesis and energy metabolism

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It is also important to consider the quality of products and equipment, including reliable sourcing, proper storage, and adherence to medical safety protocols during treatment