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Future developments already visible Recent developments in the field of GLP-1 receptor agonists have largely focused on longer-acting preparations (i.e

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Common: Nausea (28%), Diarrhea (24%), Constipation (21%), Vomiting (17%) Timing: Peak weeks 4 to 8, resolve by week 12 Discontinuation: 11.2% Orlistat: GI effects 50 to 79%, persist with fat intake Contrave: Nausea 33%, CNS effects ongoing Qsymia: Cognitive effects 20%, stimulant effects ongoing Managing Side Effects Retatrutides side effects respond well to proactive management