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7 In these emergency situations, a single low dose of rasburicase (0.02 to 0.05mg/kg up to 3mg) can be administered and it is recommended that hemodialysis be readily available in the event of clinically significant hemolysis and acute renal failure

This mechanism may help explain the lower recurrence risk observed in recent studies

1A, B) compared to empty vector-containing cells (control)

Collectively, confinement is a pathophysiologically relevant cue that can influence tumor progression significantly by altering the modes and mechanisms of cancer cell migration, promoting genomic instability, and inducing gene expression changes, which trigger EMT and provide resistance to therapeutic agents

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Prasher D.New Strategies for Prevention and Treatment of Noise-Induced Hearing Loss.The Lancet, 1998