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it is triggered by biological signalling pathways that go wrong when your gut ecosystem is out of balance

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This study demonstrated that PSSI 90 and PSSI 100 results were maintained until week 60 in patients initially treated with ixekizumab 2-week dosing who were switched to 4-week dosing schedules (79.1% and 75.9%) as well as patients continued on a ixekizumab 4-week dosing schedule (76.2% and 73.6%) [45]