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In sorafenib resistance, high PHGDH expression directly drives resistance and can be directly reversed by pharmacological inhibition

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The activity of SLC7A11 is regulated by several factors, such as the transcription factor activating transcription factor 4 (ATF4) and/or nuclear factor erythroid 2-related 2 (NRF2) [33, 34], the epigenetic regulation-associated enzyme BAP1 [35], the tumour suppressor protein p53 [36], the autophagy mechanism component BECN1 [37], and the ferroptosis inducer erastin [38]

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Maedica 5(2):116 Vagney M, Desquilbet L, Reyes-Gomez E, Delisle F, Devauchelle P, Rodriguez-Pieiro MI, Rosenberg D, de Fornel-Thibaud P (2018) Survival times for cats with hyperthyroidism treated with a 3.35 mCi iodine-131 dose: a retrospective study of 96 cases