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And if you lose weight, youre improving insulin sensitivity, she added, because youre offloading the work that the beta-cell has to do. (Jastreboff has led several clinical trials on tirzepatide and retatrutide funded by Eli Lilly and has served on the Scientific Advisory Boards for Eli Lilly, Novo Nordisk, Pfizer, Amgen, and several other companies.) How do the drugs trigger weight loss