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While Brazil nuts are an excellent source of selenium, it is possible to have too much of a good thing

Mechanistically, it has multiple hydroxyl groups that hydrogen-bond to water

A 2020 review of case reports found that self-administered coffee enemas caused adverse effects such as: abdominal pain bloody stool rectal pain or burning proctocolitis, or inflammation of the rectal lining colitis, or inflammation of the colon The review also noted three deaths following coffee enema

Cell Physiol Biochem 53(5):865886

This also opens up avenues more broadly for looking at the interplay between genetic and metabolic factors

Impact of Semaglutide on Alcohol Consumption Habits 8