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It is designed using features of natural incretin hormones but includes modifications that change its receptor activity and duration

The pharmaceutical reason is straightforward: peptides are large protein molecules that require sufficient concentration to activate their target receptors on nerve cells and organs

One analysis using national commercial data found that 30% of patients stopped treatment within four weeks, before reaching the targeted dose

We cannot rule out that the risk of certain subtypes of thyroid cancer is increased in smaller patient groups that we could not study here, for example in people with a high congenital risk of medullary thyroid cancer who are advised against using these drugs, says Peter Ueda, assistant professor at the Department of Medicine, Solna, at Karolinska Institutet

The injection route also presents practical challenges

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