This effect is not observed in other GLP-1RAs and is currently being studied by the drug manufacturers in the FOCUS trial (NCT03811561)
Beneficial effects of GLP-1 in reducing toxic protein accumulation are hypothesized to occur through the PI3K/Akt inactivation of glycogen synthase kinase 3 beta (GSK3) [82] and a possible GLP-1 mediated upregulation of IDE [83]
The MTOR inhibitor rapamycin mitigates perforant pathway neurodegeneration and synapse loss in a mouse model of Early-Stage Alzheimer-Type tauopathy
Main issues include missing drug classes or individual drugs, exclusion of relevant indications or routes of application, the handling of drugs with multiple indications, and incomplete listing of available drugs (Fig
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