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A retrospective study conducted at the University Health Network found that, in liver transplant recipients with diabetes, combination therapy reduced HbA1c and alanine aminotransferase levels more effectively than DPP-4 inhibitors. Additionally, two clinical trials in patients with Type 2 diabetes demonstrated that combination therapy significantly lowered HbA1c by 1.34% and 1.21%, compared to a 0.54% reduction with placebo, starting from a baseline of 8.0%. These findings suggest that combination therapy may be especially beneficial in the liver transplant population, where patients often experience weight gain and develop metabolic co-morbidities

These findings were supported by another study in which liraglutide improved diastolic function in diabetic patients [91, 92]

Men commonly experience metabolic changes, reduced muscle mass, and hormone fluctuations with age that can contribute to weight gain

This can help reduce feelings of fullness and nausea

Tirzepatide is a dual agonist that targets both GLP-1 and GIP receptors, which can lead to more significant improvements in blood sugar control and weight loss

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