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10.1016/j.cell.2021.04.041 135 SavcY.KrbaO

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Additional regional factors such as high baseline HBV endemicity (5-18%), dietary aflatoxin exposure, and lower NAFLD prevalence further limit direct extrapolation (105)

This gap is why clinical protocols for acute glutathione repletion -- liver support, immune challenges, detoxification -- consistently use parenteral routes rather than oral supplementation

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