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In the absence of adequate GPX4, the radical intermediates, readily produced from hydroperoxy-phospholipids, directly oxidize GSH in a 1-electron reaction to generate a strongly pro-oxidant radical, GSH

Diabetes Care 38 (1), 140149

S3696 Ischemic colitis in the setting of tirzepatide-induced constipation: a potential adverse effect

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The oral vs injection comparison shows that efficacy appears similar in clinical studies, though oral formulations have their own considerations including specific fasting requirements and potentially different GI side effect profiles

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