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There is no evidence that combining the treatments increases bleeding risk beyond what would be expected from either treatment alone, but managing patient expectations regarding cosmetic outcomes is important

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Kojic acid works on the skin's surface to help fade dark spots, acne scars, melasma, and sun damage

FOXO4-DRI a D-retro-inverso peptide made from protease-resistant D-amino acids competitively displaces endogenous FOXO4 from p53, freeing p53 to activate its apoptotic program selectively in senescent cells (Baar et al., 2017)

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