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Fetoni et al., Figure 2)

These two substitutions , the Nle4 and D-Phe7 modifications and were introduced through the systematic structure-activity relationship programme in Victor Hrubys laboratory at the University of Arizona that established the pharmacophore requirements for melanocortin receptor agonism and produced MT-1 as a more potent, metabolically stable, and pharmacologically tractable research tool than native -MSH

Vaidya adds

Cirilli I, et al

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The improvement in the level of the tested neurotransmitters and AchE was more pronounced in the therapeutic groups than in the protective ones