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These factors, including lipopolysaccharide (LPS), tumor necrosis factor-alpha (TNF-), and interleukin-1 beta (IL-1), may impede P-gp activity, activate the mitogen-activated protein kinase (MAPK) signaling pathway, and increase nuclear factor kappa-light-chain-enhancer of activated B cells (NF-B) expression in ECs

doi: 10.1111/dom.15802

The animal experiments were in accordance with the statement on animal Ethics Review of Hebei North University (Approval No.HBNU2023012006)

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Despite this report, other groups weren't able to replicate these results (53)

Encapsulation efficiency improved substantially, enabling extended experimental timelines