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doi: 10.1371/journal.pone.0088427 38 PinterASzatmariSJrHorvathTPenzlinAIBarlinnKSiepmannMet al

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If you try to treat based upon outcomes, Okay, I am depressed, youre either going to treat the mechanism we think is causing the depression, or well use an intervention and reassess your outcome of depression after a number of weeks

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49 Even more interestingly, patients who showed an improvement in endothelial function after intraarterial infusion with vitamin C (showing an evidence of endothelial dysfunction caused by increased oxidative stress), had a worse prognosis as compared with patients with a low or no vitamin C effects

Therefore, overuse and rapid depletion of glutathione results in a deficiency of methylcobalamin and a number of neuropathological disease states related to a downstream neurotransmitter imbalance (James et al., 2004