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These effects are generally dose-dependent and tend to improve as the body adjusts to the medication

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Retention of 5-methyl-THF fortificant during breadmaking varied depending on the bread size (so on baking time) and it was only 50% of that of folic acid in breads of the same size 127

(PubMed) Alhazzani W, Jacobi J, Sindi A, et al

Approximately 70% of American people are obese or overweight, which is a serious health condition linked to a number of the top causes of mortality, such as cardiovascular diseases