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discovered that iron supplementation could alter gut microbial homeostasis and exacerbate intestinal inflammation in a murine model of CD (138)

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10.1097/00003086-199305000-00038 [DOI] [PubMed] [Google Scholar] Kawakami T., Kawai T., Takei N., Kise T., Eda S., Urist M

Used in explaining increased frequency of seizures in epilepsy and progression of bipolar disorder in humans. Jason et al have recently (2011) proposed kindling as an etiological model for ME/CFS : Kindling might represent a heuristic model for understanding the etiology of Myalgic Encephalomyelitis/chronic fatigue syndrome (ME/CFS)

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