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These timelines reflect typical clinical observations, not guaranteed outcomes

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Proceedings of the National Academy of Sciences USA , 74(3), 12821286

One of the most promising strategies to overcome this multi-drug resistance, MRP1-mediated CS, relies on the ability of certain ligands of MRP1 to induce a massive MRP1-dependent GSH efflux, that depletes the cells of their anti-oxidant defense, leading to their selective cell death 15

Differentiation of opioid drug effects by hierarchical multi-site phosphorylation