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Cocco et al., in a cohort of 1756 Sardinian men with G6PD deficiency, reported a standardized mortality ratio for CVD of 0.28 versus the 1.0 reference value for ischemic heart disease and 0.22 versus 1.0 for cerebrovascular disease [8]

doi: 10.1038/s41419-020-2298-2

doi: 10.1038/s41577-024-01026-4 9 LeoneRDPowellJD

7 Fonseca, V.A., et al., Reductions in Insulin Resistance are Mediated Primarily via Weight Loss in Subjects With Type 2 Diabetes on Semaglutide

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Mechanisms and consequences Whilst researching a related topic for a soon-to-be-published MedNut Mail email, I came across this diagram and asked the question what are the likely mechanisms of action for metformin to alter pyridoxines (vitamin B6) metabolic pathway? Early evidence indicates metformin use is associated with a higher risk of B6 deficiency, with one study estimating a risk increase of about 48%