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J.TaoL.et al (2011)

Rushing from 1mg to 8mg or 12mg over just a few weeks creates an adaptation crisis

After numerous case reports validated the role of LRT as an effective treatment of LAST, the American Society of Regional Anesthesia and Pain Medicine (ASRA) issued a practice advisory in 2010 followed in 2012 by a checklist for managing LAST ( Figure 1 )