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Side effects are one contributing factor with respect to discontinuation

In one randomized, double-blind trial involving 251 adolescents aged 12-18 years with obesity who did not respond well to lifestyle modification alone, adding liraglutide was shown to increase weight loss

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Here, we describe (4 + 3) and (3 + 2) indole annulation strategies that quickly generate complex indole heterocycle libraries that contain novel cyclohepta- and cyclopenta[ b ]indoles, respectively

Retatrutide showing promise in obesity (and type 2 diabetes)