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It is important to note that including patients with a known history of depression and/or anxiety in such studies could bias the results, as these patients are more prone to experience a new episode, which could be wrongfully attributed to GLP-1 RAs drugs

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Moreover, the weight loss achieved with GLP-1 RAs combined with lifestyle intervention approaches is comparable to that of surgical intervention, far surpassing the results adolescents can achieve through lifestyle changes alone ( This paper is a narrative review that references the SANRA guidelines for narrative reviews, but was not strictly written according to these guidelines

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