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Efficacy and safety of the SGLT2 inhibitor empagliflozin versus placebo and the DPP-4 inhibitor linagliptin versus placebo in young people with type 2 diabetes (DINAMO): a multicentre, randomised, double-blind, parallel group, phase 3 trial

These findings reinforce an important principle: greater pharmacologic strength does not always translate to optimal individual outcomes

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Design, synthesis, biological screening, and molecular docking studies of piperazine-derived constrained inhibitors of DPP-IV for the treatment of type 2 diabetes

10.1210/jcem.81.11.8923850 78 RudmanD.FellerA

These advanced formulations could potentially overcome the pharmacokinetic limitations that have historically constrained SFNs clinical efficacy