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Cartilage faces even greater obstacles given avascular nature (no blood vessels penetrating tissue), low cell density (chondrocytes sparse within extensive extracellular matrix), minimal metabolic activity (slow turnover and repair), and mechanical loading challenges (constant stress impeding healing)

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19 Sarkar R, Ranjan R, Garg S, Garg VK, Sonthalia S, Bansal S

However, lixisenatide in the ELIXA trial did not significantly alter the incidence of MACE, and exnatide in the EXSCEL trial lower the risk of MACE with no significant difference

44: 631-5 reported that 72% of 29 patients remained clear for 4.1 years after use for 5/w for 6 weeks or bd 6w or bd 10w

(2) from arcade 1 to the next arcade (arcade 2), middle arcade inside ligations (or previous ligation) (1-2, Figures 2, 5-8, 21 and 22)