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While this concept had been explored by academic groups and other pharmaceutical companies, Eli Lilly was uniquely positioned to execute it given their experience engineering multi-receptor peptides

However, it would be interesting to see if similar bias occurs at central GLP-1r populations and whether this alters the synaptic and behavioral outcomes of GLP-1r agonism

References 1 LacroixAFeeldersRAStratakisCANiemanLK

Protein folding and misfolding

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Control mice continued to be fed 26% protein content breeder chow (LabDiet, St Louis, MO) ad libitum